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The project aims to identify and validate specific biomarkers of heart failure in order to prevent the development of the disease affecting elderly population.

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The 12 million euros grant of the European Commission will be dedicated to the HOMAGE consortium for research on heart failure, a serious illness altering myocardial activity which affects more than 6. Indeed, the prevalence of heart failure is increasing worldwide due to an ageing population as well as a rising trend of risk factors for heart disease such as diabetes, obesity and hypertension.

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Heart failure is a major cause of mortality and morbidity in the world and remains the most frequent cause of hospitalization for patients over 65 years old. The costs related to heart failure have been estimated around 1.

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Screening tests are usually based on blood pressure, glycaemic and cholesterol control. Although they are protection du pénis to detect high risk patients, they are limited regarding their sensitivity and specificity.

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During the past decade, promising biomarkers such as natriuretic peptides have been identified to diagnose heart failure, but their predictive value remains relatively poor. The HOMAGE consortium is willing to validate more specific and more sensitive biomarkers which should facilitate an early detection of the disease in patients at risk.

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This approach aims to validate promising biomarker candidates by crossing a large volume of data genomics, proteomics, miRNomics, transcriptomics and metabolomics. This would permit scientists to understand new pathophysiological mechanisms, signaling pathways and identify new therapeutic targets to prevent heart failure. The European researchers will firstly identify biomarker candidates in blood and study their predictive value for heart failure and common co-morbidities associated with ageing renal impairment, cognitive disorders….

Subsequently, HOMAGE will lead a clinical trial to look for novel treatments of heart failure that can be targeted specifically to those patients at risk.

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